Catalytic Properties of Human Manganese Superoxide Dismutase
نویسندگان
چکیده
منابع مشابه
Manganese Superoxide Dismutase (MnSOD)
2 Introduction 3 Phylogenetic distribution and subcellular localization 3 Kinetics and mechanism 3 Molecular and chemical structure 5 Biological significance 8 Summary 9 References 10 Abstract Manganese superoxide dismutase (MnSOD) is the primary antioxidant enzyme that protects cells from oxidative stress by catalyzing dismutation of superoxide (O2 ) to hydrogen peroxide and oxygen in the mito...
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Submit Manuscript | http://medcraveonline.com MOJ Anat Physiol 2015, 1(2): 00006 was neonatal lethal. Due to background modifications, a small percentage of knockout mice showed dilated cardiomyopathy indicating increased vulnerability to oxidative injury in the cardiac myocytes [1]. Ikegami et al. [3] successfully generated tissuespecific MnSOD conditional knockout mice that would provide a us...
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The mitochondrion is vital for many metabolic pathways in the cell, contributing all or important constituent enzymes for diverse functions such as β-oxidation of fatty acids, the urea cycle, the citric acid cycle, and ATP synthesis. The mitochondrion is also a major site of reactive oxygen species (ROS) production in the cell. Aberrant production of mitochondrial ROS can have dramatic effects ...
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The manganese and iron SODs (superoxide dismutases) form a superfamily of closely related antioxidant defence metalloenzymes. MnSOD requires Mn (not Fe) for activity. However, when MnSOD is expressed in Escherichia coli grown in medium supplemented with ferrous salts, Fe substitutes for Mn in the active site, reflecting relatively indiscriminate uptake of either Mn or Fe and a surprisingly low ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1996
ISSN: 0021-9258
DOI: 10.1074/jbc.271.30.17687